This research explored the range of strategies that have been adopted by the police in four jurisdictions across Australia to manage risks involved in police interactions with persons who are intoxicated or under the influence of alcohol and other drugs. The primary aim was to develop a best practice framework to help guide the development of police policies and practices in identifying, responding to and managing intoxication and withdrawal. The C.A.L.M framework (Control, Assess, Liaise and Manage) is designed to assist the police in identifying risks and considerations related to intoxication and withdrawal during each stage of offender management. Regular engagement across police jurisdictions was identified as important in the development and maintenance of best practice.