Current methods of reporting the impact of proceeds of crime action typically under-report their effect on drug trafficking activity. The Proceeds of Crime Drug Disruption Index (POCDDI) has been developed, to better capture the short and medium-term impact of proceeds of crime action, taking into account current knowledge regarding the profitability and reinvestment behaviour of drug traffickers at different stages of the production and distribution process. Results support the argument that the raw value of confiscated assets substantially underestimate the real impact of proceeds of crime action, with medium-term estimates suggesting an impact of 11.9 times raw value for distributors, importers and producers of illicit drugs. Analyses of data provided by the Australian Federal Police also examined factors associated with successful or unsuccessful proceeds of crime actions. (Abstract, edited)